L-Ascorbic acid
(HB1238)- Data
- Support & Resources
Product overview
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Name
L-Ascorbic acid
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Short description
Antioxidant. Enhances iPSC generation and increases reprogramming efficiency.
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Biological description
Naturally occurring antioxidant.
Enhances iPSC generation and increases reprogramming efficiency. Also supports mesenchymal stem cell proliferation and promotes differentiation of osteoblasts from human / mouse MSCs and mESCs.
Also a Cav3.2 channel inhibitor (IC50 = 6.5 µM) which exhibits little or no activity at Cav3.1 and Cav3.3 channels.Commonly used with dexamethasone and β-Gly for osteogenic differentiation of stem cells.
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Alternative names
L-Ascorbate
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Biological action
Activator
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Purity
>99%
- Citations
Properties
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Chemical name
3-Oxo-L-gulofuranolactone
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Molecular Weight
176.12
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Chemical structure
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Molecular Formula
C6H8O6
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CAS Number
50-81-7
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PubChem identifier
54670067
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SMILES
C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
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InChi
InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
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InChiKey
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
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MDL number
MFCD00064328
Storing and Using Your Product
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Storage instructions
Room temperature
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Solubility overview
Soluble in water (500mM) and in DMSO (100mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for L-Ascorbic acid
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Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.
Nelson MT et al (2007) J Neurosci 27(46) : 12577-83.PubMedID: 18003836 -
Vitamin C as an antioxidant: evaluation of its role in disease prevention.
Padayatty SJ et al (2003) J Am Coll Nutr 22(1) : 18-35.PubMedID: 12569111 -
Protective action of an anti-oxidant (L-Ascorbic acid) against genotoxicity and cytotoxicity in mice during p-DAB-induced hepatocarcinogenesis.
Surjyo B et al (2004) Indian J Cancer 41(2) : 72-80.PubMedID: 15318012