L-Ascorbic acid

(HB1238)

Order: HB1238

Pack	Price	Qty
25g	$30
100g	$72

(HB1238)

Data

Product overview

Name
L-Ascorbic acid
Short description
Antioxidant. Enhances iPSC generation and increases reprogramming efficiency.
Biological description

Naturally occurring antioxidant.

Enhances iPSC generation and increases reprogramming efficiency. Also supports mesenchymal stem cell proliferation and promotes differentiation of osteoblasts from human / mouse MSCs and mESCs.

Also a Ca_v3.2 channel inhibitor (IC₅₀ = 6.5 µM) which exhibits little or no activity at Ca_v3.1 and Ca_v3.3 channels.

Commonly used with dexamethasone and β-Gly for osteogenic differentiation of stem cells.
Alternative names
L-Ascorbate
Biological action
Activator
Purity
>99%
Citations
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Chemical name
3-Oxo-L-gulofuranolactone
Molecular Weight
176.12
Chemical structure
Molecular Formula
C₆H₈O₆
CAS Number
50-81-7
PubChem identifier
54670067
SMILES
C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
InChi
InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
InChiKey
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
MDL number
MFCD00064328

Storage instructions
Room temperature
Solubility overview
Soluble in water (500mM) and in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.

Nelson MT et al (2007) J Neurosci 27(46) : 12577-83.
PubMedID: 18003836
Vitamin C as an antioxidant: evaluation of its role in disease prevention.

Padayatty SJ et al (2003) J Am Coll Nutr 22(1) : 18-35.
PubMedID: 12569111
Protective action of an anti-oxidant (L-Ascorbic acid) against genotoxicity and cytotoxicity in mice during p-DAB-induced hepatocarcinogenesis.

Surjyo B et al (2004) Indian J Cancer 41(2) : 72-80.
PubMedID: 15318012

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