L-Ascorbic acid

(HB1238)

Product overview

  • Name
    L-Ascorbic acid
  • Short description
    Antioxidant. Enhances iPSC generation and increases reprogramming efficiency.
  • Biological description

    Naturally occurring antioxidant.

    Enhances iPSC generation and increases reprogramming efficiency. Also supports mesenchymal stem cell proliferation and promotes differentiation of osteoblasts from human / mouse MSCs and mESCs.


    Also a Cav3.2 channel inhibitor (IC50 = 6.5 µM) which exhibits little or no activity at Cav3.1 and Cav3.3 channels.

    Commonly used with dexamethasone and β-Gly for osteogenic differentiation of stem cells.

  • Alternative names
    L-Ascorbate
  • Biological action
    Activator
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    3-Oxo-L-gulofuranolactone
  • Molecular Weight
    176.12
  • Chemical structure
    L-Ascorbic acid  [50-81-7]
  • Molecular Formula
    C6H8O6
  • CAS Number
    50-81-7
  • PubChem identifier
    54670067
  • SMILES
    C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
  • InChi
    InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
  • InChiKey
    CIWBSHSKHKDKBQ-JLAZNSOCSA-N
  • MDL number
    MFCD00064328

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (500mM) and in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for L-Ascorbic acid

  • Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.

    Nelson MT et al (2007) J Neurosci 27(46) : 12577-83.
    PubMedID: 18003836
  • Vitamin C as an antioxidant: evaluation of its role in disease prevention.

    Padayatty SJ et al (2003) J Am Coll Nutr 22(1) : 18-35.
    PubMedID: 12569111
  • Protective action of an anti-oxidant (L-Ascorbic acid) against genotoxicity and cytotoxicity in mice during p-DAB-induced hepatocarcinogenesis.

    Surjyo B et al (2004) Indian J Cancer 41(2) : 72-80.
    PubMedID: 15318012