Product overview

  • Name
    L-NMMA
  • Short description
    Competitive, selective NOS inhibitor
  • Biological description
    Competitive and selective nitric oxide synthase (NOS) inhibitor (IC50 values are 6.6, 4.9 and 3.5 μM for iNOS, nNOS and eNOS respectively). Also inhibits cyclic GMP (IC50 = 2.9 μM). Displays hypertensive properties.
  • Biological action
    Inhibitor
  • Our products in action

Properties

  • Chemical name
    N(omega)-Monomethyl-L-Arginine Acetate
  • Molecular Weight
    248.28
  • Chemical structure
    L-NMMA [53308-83-1]
  • Molecular Formula
    C7H16N4O2.CH3CO2H
  • CAS Number
    53308-83-1
  • PubChem identifier
    135242
  • SMILES
    CC(=O)O.CN=C(N)NCCC[C@@H](C(=O)O)N
  • InChi
    InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
  • InChiKey
    IKPNWIGTWUZCKM-JEDNCBNOSA-N
  • MDL number
    MFCD00069311

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (50 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for L-NMMA

  • Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.

    Rees DD et al (1990) Br J Pharmacol 101(3) : 746-52.
    PubMedID: 1706208
  • Nitric oxide synthases: structure, function and inhibition.

    Alderton WK et al (2001) Biochem J 357(Pt 3) : 593-615.
    PubMedID: 11463332
  • L-NMMA (a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock.

    Cotter G et al (2000) Circulation 101(12) : 1358-61.
    PubMedID: 10736276
  • Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function.

    Cardounel AJ et al (2007) J Biol Chem 282(2) : 879-87.
    PubMedID: 17082183

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