In my cart

You have no items in your shopping cart.

Lactacystin

(HB3953)
Data

Product overview

  • Name
    Lactacystin
  • Short description
    Potent, selective, irreversible proteasome inhibitor
  • Biological description
    Potent, selective, cell-permeable and irreversible proteasome inhibitor. Binds the active site N-terminal threonine residue of the 20S proteasome catalytic β-subunit to block proteasome activity. Shows anticancer and anti-adipogenic activity. Also induces neuritogenesis, apoptosis and autophagy.
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester
  • Molecular Weight
    376.4
  • Chemical structure
    Lactacystin [133343-34-7]
  • Molecular Formula
    C15H24N2O7S
  • CAS Number
    133343-34-7
  • PubChem identifier
    6610292
  • SMILES
    O=C1N[C@]([C@@](SC[C@H](NC(C)=O)[C@](O)=O)=O)([C@H](C(C)C)O)[C@@H](O)[C@H]1C
  • Source
    Streptomyces lactacystinnaeus
  • InChi
    InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
  • InChiKey
    DAQAKHDKYAWHCG-MJZHQVMOSA-N
  • MDL number
    MFCD01076525
  • Appearance
    White to off-white solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in water, and in DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Support & Resources

Reviews & Product Guides