Lamotrigine

(HB0368)

Product overview

  • Name
    Lamotrigine
  • Short description
    Na2+ / K+ / Ca2+ channel inhibitor. Anticonvulsant.
  • Biological description
    Anticonvulsant. Inhibits voltage-dependent Na2+ channels, K+ and Ca2+ channels. Inhibits α4β2-nACh receptor mediated currents and reduces GABAA receptor transmission. Inhibits 5-HT, noradrenaline and dopamine uptake into synaptosomes (IC50 values are 474, 239 and 322 µM respectively). Shows anticonvulsant and anti-bipolar actions. Blood-brain barrier permeable.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
  • Molecular Weight
    256.09
  • Chemical structure
    Lamotrigine  [84057-84-1]
  • Molecular Formula
    C9H7Cl2N5
  • CAS Number
    84057-84-1

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in ethanol (10mM) or DMSO (100mM)

References for Lamotrigine

  • Modulation of calcium and potassium currents by lamotrigine.

    Grunze H et al (1998) Neuropsychobiology 38(3) : 131-8.
    PubMedID: 9778600
  • Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disorders.

    Braga MF et al (2002) Neuropharmacology 42(4) : 522-9.
    PubMedID: 11955522
  • Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.

    Southam E et al (1998) Eur J Pharmacol 358(1) : 19-24.
    PubMedID: 9809864
  • The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic acetylcholine receptors.

    Zheng C et al (2010) J Pharmacol Exp Ther 335(2) : 401-8.
    PubMedID: 20688974

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