Product overview

  • Name
  • Short description
    Selective group III mGluR agonist. Inhibits synaptic transmission.
  • Biological description

    Selective group III mGluR agonist (EC50 values are 0.9, 252, 0.06-0.6 μM at mGlu4, mGlu7, mGlu8 receptors respectively and >1000 μM at other mGluRs).

    Also a weak NMDA receptor agonist.

    Potent synaptic depressant.

    Reduces glutamate release, inhibits glutamate-mediated EPSPs in the hippocampus, olfactory cortex and spinal cord and inhibits long term potentiation (LTP) in vivo.

    Also inhibits GABA release and reversibly reduces GABA-mediated inhibitory post-synaptic potential (IPSP) amplitude.

    Additionally shows neuroprotective properties.

  • Biological action
  • Purity
  • Citations


  • Chemical name
    L-(+)-2-Amino-4-phosphonobutyric acid
  • Molecular Weight
  • Chemical structure
    L-AP4  [23052-81-5]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (5mM) and in 0.1M NaOH (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for L-AP4

  • L-AP4, a potent agonist of group III metabotropic glutamate receptor, decreases central action of angiotensin II.

    Fedosiewicz-Wasiluk M et al (2002) Pol J Pharmacol 54(5) : 415-22.
    PubMedID: 12593528
  • The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain.

    Tones MA et al (1995) Neuroreport 7(1) : 117-20.
    PubMedID: 8742431
  • Changes of mGluR4 and the effects of its specific agonist L-AP4 in a rodent model of diffuse brain injury.

    Zhou F et al (2003) J Clin Neurosci 10(6) : 684-8.
    PubMedID: 14592619
  • Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

    Schoepp DD (2001) J Pharmacol Exp Ther 299(1) : 12-20.
    PubMedID: 11561058
The following papers have cited the use of L-AP4 (HB0370) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • NMDA receptors contribute to retrograde synaptic transmission from ganglion cell photoreceptors to dopaminergic amacrine cells

    Liu et al(2017) Frontier in Cellular Neuroscience 11:279 : (1-13)