Product overview

  • Name
    L-AP4
  • Short description
    Selective group III mGluR agonist. Inhibits synaptic transmission.
  • Biological description

    Selective group III mGluR agonist (EC50 values are 0.9, 252, 0.06-0.6 μM at mGlu4, mGlu7, mGlu8 receptors respectively and >1000 μM at other mGluRs).

    Also a weak NMDA receptor agonist.


    Potent synaptic depressant.

    Reduces glutamate release, inhibits glutamate-mediated EPSPs in the hippocampus, olfactory cortex and spinal cord and inhibits long term potentiation (LTP) in vivo.

    Also inhibits GABA release and reversibly reduces GABA-mediated inhibitory post-synaptic potential (IPSP) amplitude.


    Additionally shows neuroprotective properties.

  • Biological action
    Agonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    L-(+)-2-Amino-4-phosphonobutyric acid
  • Molecular Weight
    183.1
  • Chemical structure
    L-AP4  [23052-81-5]
  • Molecular Formula
    C4H10NO5P
  • CAS Number
    23052-81-5
  • PubChem identifier
    179394
  • SMILES
    C(CP(=O)(O)O)[C@@H](C(=O)O)N
  • Source
    Synthetic
  • InChi
    InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
  • InChiKey
    DDOQBQRIEWHWBT-VKHMYHEASA-N
  • MDL number
    MFCD00083244
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (5mM) and in 0.1M NaOH (100mM)

References for L-AP4

  • L-AP4, a potent agonist of group III metabotropic glutamate receptor, decreases central action of angiotensin II.

    Fedosiewicz-Wasiluk M et al (2002) Pol J Pharmacol 54(5) : 415-22.
    PubMedID: 12593528
  • The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain.

    Tones MA et al (1995) Neuroreport 7(1) : 117-20.
    PubMedID: 8742431
  • Changes of mGluR4 and the effects of its specific agonist L-AP4 in a rodent model of diffuse brain injury.

    Zhou F et al (2003) J Clin Neurosci 10(6) : 684-8.
    PubMedID: 14592619
  • Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

    Schoepp DD (2001) J Pharmacol Exp Ther 299(1) : 12-20.
    PubMedID: 11561058