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Lavendustin C

(HB0376)
Data

Product overview

  • Name
    Lavendustin C
  • Short description
    Potent EGFR tyrosine kinase inhibitor
  • Biological description
    Potent EGF receptor tyrosine kinase (IC50 = 11 nM) and c-src (IC50 = 500 nM) inhibitor. Inhibits Ca2+/calmodulin kinase II (IC50 = 200 nM). Blocks LTP induction.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    5-((2,5-Dihydroxybenzyl)amino)-2-hydroxybenzoic acid
  • Molecular Weight
    275.3
  • Chemical structure
    Lavendustin C  [125697-93-0]
  • Molecular Formula
    C14H13NO5
  • CAS Number
    125697-93-0
  • PubChem identifier
    3896
  • SMILES
    C1=CC(=C(C=C1NCC2=C(C=CC(=C2)O)O)C(=O)O)O

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO or methanol
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Lavendustin C

  • Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus.

    Onoda T et al (1989) J Nat Prod 52(6) : 1252-7.
    PubMedID: 2614420
  • Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors.

    O'Dell TJ et al (1991) Nature 353(6344) : 558-60.
    PubMedID: 1656271
  • Involvement of Ca2+/calmodulin-dependent protein kinase II in endothelial NO production and endothelium-dependent relaxation.

    Schneider JC et al (2003) Am J Physiol Heart Circ Physiol 284(6) : H2311-9.
    PubMedID: 12560211
  • Role of the mitogen-activated protein kinases and tyrosine kinases during leukotriene B4-induced eosinophil activation.

    Lindsay MA et al (1998) J Leukoc Biol 64(4) : 555-62.
    PubMedID: 9766637
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