Leptomycin B

(HB4219)

Product overview

  • Name
    Leptomycin B
  • Short description
    Antibiotic. Inhibits nuclear export of protiens.
  • Biological description
    Antibiotic. Binds and inhibits the CRM1 protein to inhibit nuclear export of proteins. Shown to inhibit the nuclear export of the HIV regulatory protein Rev.

    Also shows antifungal activity.

  • Alternative names
    CI 940, LMB
  • Biological action
    Antibiotic
  • Citations

Properties

  • Chemical name
    (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
  • Molecular Weight
    540.74
  • Molecular Formula
    C33H48O6
  • CAS Number
    87081-35-4
  • PubChem identifier
    6917907
  • SMILES
    CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
  • InChiKey
    YACHGFWEQXFSBS-XYERBDPFSA-N
  • MDL number
    MFCD06795848
  • Appearance
    White to off-white

Storing and Using Your Product

  • Storage instructions
    -20 °C;
  • Solubility overview
    Soluble in ethanol
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

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