Product overview

Name Leptomycin B
Alternative names CI 940, LMB
Purity >98%
Description Antibiotic. Inhibits nuclear export of protiens.
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Biological Data

Biological description Antibiotic. Binds and inhibits the CRM1 protein to inhibit nuclear export of proteins. Shown to inhibit the nuclear export of the HIV regulatory protein Rev.

Also shows antifungal activity.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in ethanol
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
Molecular Weight 540.74
Molecular Formula C33H48O6
CAS Number 87081-35-4
PubChem identifier 6917907
SMILES CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
InChiKey YACHGFWEQXFSBS-XYERBDPFSA-N
MDL number MFCD06795848
Appearance White to off-white