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Linopirdine dihydrochloride


Product overview

  • Name
    Linopirdine dihydrochloride
  • Short description
    Kv7 channel blocker
  • Biological description
    Kv7 channel blocker. Increases ACh release in the brain and blocks M currents (IC50 = 2.4 µM). Induces increased neocortical Fos protein expression in aged rats. Also agonises TRPV1 (transient receptor potential vanilloid type 1) channel. Shows excitatory actions on nociceptors and shows cognition enhancing actions.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride
  • Molecular Weight
  • Chemical structure
    Linopirdine dihydrochloride  [113168-57-3]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM) and in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Linopirdine dihydrochloride

  • The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1.

    Neacsu C et al (2010) J Pharmacol Sci 114(3) : 332-40.
    PubMedID: 21099148
  • Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons.

    Schnee ME et al (1998) J Pharmacol Exp Ther 286(2) : 709-17.
    PubMedID: 9694925
  • The acetylcholine release enhancer linopirdine induces Fos in neocortex of aged rats.

    Dent GW et al (2001) Neurobiol Aging 22(3) : 485-94.
    PubMedID: 11378256
Our products in action
The following papers have cited the use of Linopirdine dihydrochloride (HB1082) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • The paracetamol metabolite N-acetylp-benzoquinone imine reduces excitability in first- and second-order neurons of the pain pathway through actions on KV7 channels.

    Ray et al (2019) Pain. 160(4) : 954-964
    PubMedID: 30601242
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