Linopirdine dihydrochloride

(HB1082)

Product overview

  • Name
    Linopirdine dihydrochloride
  • Short description
    Kv7 channel blocker
  • Biological description
    Kv7 channel blocker. Increases ACh release in the brain and blocks M currents (IC50 = 2.4 µM). Induces increased neocortical Fos protein expression in aged rats. Also agonises TRPV1 (transient receptor potential vanilloid type 1) channel. Shows excitatory actions on nociceptors and shows cognition enhancing actions.
  • Biological action
    Blocker
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride
  • Molecular Weight
    464.39
  • Chemical structure
    Linopirdine dihydrochloride  [113168-57-3]
  • Molecular Formula
    C26H21N3O.2HCl
  • CAS Number
    113168-57-3
  • PubChem identifier
    14209557
  • SMILES
    C1=CC=C(C=C1)N2C3=CC=CC=C3C(C2=O)(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl
  • InChi
    InChI=1S/C26H21N3O.2ClH/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22;;/h1-17H,18-19H2;2*1H
  • InChiKey
    ZEVVHCGTTNRYOY-UHFFFAOYSA-N
  • MDL number
    MFCD00867216

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM) and in DMSO (100 mM)

References for Linopirdine dihydrochloride

  • The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1.

    Neacsu C et al (2010) J Pharmacol Sci 114(3) : 332-40.
    PubMedID: 21099148
  • Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons.

    Schnee ME et al (1998) J Pharmacol Exp Ther 286(2) : 709-17.
    PubMedID: 9694925
  • The acetylcholine release enhancer linopirdine induces Fos in neocortex of aged rats.

    Dent GW et al (2001) Neurobiol Aging 22(3) : 485-94.
    PubMedID: 11378256

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