Loperamide hydrochloride

(HB0385)

Product overview

  • Name
    Loperamide hydrochloride
  • Short description
    Potent, selective µ-opioid receptor agonist
  • Biological description
    Potent and selective µ-opioid receptor agonist (Ki values are 3, 48 and 1156 nM for µ, δ and κ). Blocks voltage-activated calcium channels and also NMDA receptor Ca2+ influx at higher concentrations. Shows antidiarrheal and antihyperalgesic actions.
  • Biological action
    Agonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamidehydrochloride
  • Molecular Weight
    513.51
  • Chemical structure
    Loperamide hydrochloride  [34552-83-5]
  • Molecular Formula
    C29H33ClN2O2.HCl
  • CAS Number
    34552-83-5

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in ethanol (50mM) or DMSO (50mM)

References for Loperamide hydrochloride

  • Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity.

    DeHaven-Hudkins DL et al (1999) J Pharmacol Exp Ther 289(1) : 494-502.
    PubMedID: 10087042
  • Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons.

    Church J et al (1994) Mol Pharmacol 45(4) : 747-57.
    PubMedID: 8183255
  • Maitotoxin-elicited calcium influx in cultured cells. Effect of calcium-channel blockers.

    Daly JW et al (1995) Biochem Pharmacol 50(8) : 1187-97.
    PubMedID: 7488233

Reviews & Product Guides