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Loperamide hydrochloride


Product overview

  • Name
    Loperamide hydrochloride
  • Short description
    Potent, selective µ-opioid receptor agonist
  • Biological description
    Potent and selective µ-opioid receptor agonist (Ki values are 3, 48 and 1156 nM for µ, δ and κ). Blocks voltage-activated calcium channels and also NMDA receptor Ca2+ influx at higher concentrations. Shows antidiarrheal and antihyperalgesic actions.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    Loperamide hydrochloride  [34552-83-5]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in ethanol (50mM) or DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Loperamide hydrochloride

  • Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity.

    DeHaven-Hudkins DL et al (1999) J Pharmacol Exp Ther 289(1) : 494-502.
    PubMedID: 10087042
  • Loperamide blocks high-voltage-activated calcium channels and N-methyl-D-aspartate-evoked responses in rat and mouse cultured hippocampal pyramidal neurons.

    Church J et al (1994) Mol Pharmacol 45(4) : 747-57.
    PubMedID: 8183255
  • Maitotoxin-elicited calcium influx in cultured cells. Effect of calcium-channel blockers.

    Daly JW et al (1995) Biochem Pharmacol 50(8) : 1187-97.
    PubMedID: 7488233
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