The store will not work correctly in the case when cookies are disabled.
Biological Data
| Biological description | Selective, non-peptide AT1 antagonist which inhibits classical actions of angiotensin II.
Also down regulates TGF-β regulation. Shows anti-hypertensive action.
Recently studied as part of COVID-19 compound repurposing. |
Solubility & Handling
| Storage instructions | RT (desiccate) |
| Solubility overview | Soluble in water (100mM) and in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt |
| Chemical structure | ![Losartan Potasssium [124750-99-8] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Losartan Potasssium [124750-99-8]") |
| Molecular Formula | C22H22ClKN6O |
| PubChem identifier | 11476710 |
| SMILES | CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C3=CC=CC=C3C(N=N4)=NN4[K])C=C2 |
| InChi | InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1 |
| InChiKey | OXCMYAYHXIHQOA-UHFFFAOYSA-N |
References for Losartan Potasssium
References are publications that support the biological activity of the product
-
Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics
Gurwitz (2020) Drug Dev Res. : 1002/ddr.21656 -
Long-term prehypertension treatment with losartan effectively prevents brain damage and stroke in stroke-prone spontaneously hypertensive rats
He et al (2019) Int J Mol Med. 33(2) : 301-9 -
The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma
Coulson et al (2017) Oncotarget 8(12) : 18640-18656
Selective, non-peptide AT1 antagonist
![Losartan Potasssium [124750-99-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2977_1.png "Losartan Potasssium [124750-99-8]")
Understanding purity and quality - a guide for life scientists
