L-Quisqualic acid

(HB0387)

Product overview

  • Name
    L-Quisqualic acid
  • Short description
    AMPA receptor agonist / group I mGlu agonist
  • Biological description

    AMPA receptor agonist / group I mGlu agonist.

    Sensitizes neurons to excitatory amino acid analogues such as L-AP4, L-AP6 and L-AbetaH ("the Quis effect").

    Can act as an excitotoxin and is used to lesion areas of the brain in rat models.

  • Biological action
    Agonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
  • Molecular Weight
    189.13
  • Chemical structure
    L-Quisqualic acid  [52809-07-1]
  • Molecular Formula
    C5H7N3O5
  • CAS Number
    52809-07-1

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in NaOH(aq) (100mM, 1eq. NaOH) or water (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for L-Quisqualic acid

  • L-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization.

    Chase LA et al (2001) Neuroscience 106(2) : 287-301.
    PubMedID: 11566501
  • C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals.

    Giovannelli L et al (1998) J Neural Transm 105(8-9) : 935-48.
    PubMedID: 9869327
  • Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury.

    Lee JW et al (2008) Neurosci Lett 439(2) : 212-5.
    PubMedID: 18524486
  • Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.

    Littman L et al (1995) Neuropharmacology 34(8) : 829-41.
    PubMedID: 8532164