Product overview

Name LSL60101
Alternative names Garsevil
Purity >98%
Description

Selective I2-imidazoline receptor ligand

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Biological Data

Biological description

Selective, orally available I2-imidazoline receptor ligand (Ki ratio = 286 for α2 / I2 receptors). Induces morphological/biochemical changes to astroglia, reduces apoptosis and modulates oxidative stress to show neuroprotective effects. Chronic low-dose treatment of LSL60101 also reverses cognitive deficits and impaired social behaviour in 5XFAD mice to alter Alzheimer's disease markers such as glial activation and synaptic dysfunction. Both LSL60101 treatment and LSL60101 / donepezil combination treatment decreases amyloid-β40 and amyloid-β42 levels, amyloid-β plaque number and tau hyperphosphorylation to attenuate amyloid-β pathology in 5XFAD brains.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM), and in ethanol (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-(Benzofuran-2-yl)-1H-imidazole
Molecular Weight 184.2
Chemical structure LSL60101 [150985-54-9] Chemical Structure
Molecular Formula C11H8N2O
CAS Number 150985-54-9
PubChem identifier 3073596
SMILES C1=CC=C2C(=C1)C=C(O2)C3=NC=CN3
Source Synthetic
InChi InChI=1S/C11H8N2O/c1-2-4-9-8(3-1)7-10(14-9)11-12-5-6-13-11/h1-7H,(H,12,13)
InChiKey VBFQIUOSXHUWCT-UHFFFAOYSA-N
Appearance Off-white solid

References for LSL60101

References are publications that support the biological activity of the product
  • Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease.

    Rodriguez-Arévalo S et al (2021) European journal of medicinal chemistry 222 : 113540
  • Disease-modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil.

    Vasilopoulou F et al (2021) British journal of pharmacology 178 : 3017-3033
  • Exploring the antidepressant-like potential of the selective I<sub>2</sub>-imidazoline receptor ligand LSL 60101 in adult male rats.

    Hernández-Hernández E et al (2021) Pharmacological reports : PR 73 : 288-295
  • LSL 60101, a selective ligand for imidazoline I2 receptors, on glial fibrillary acidic protein concentration.

    Alemany R et al (1995) European journal of pharmacology 280 : 205-10

4 Item(s)