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LY 294002 hydrochloride


Product overview

  • Name
    LY 294002 hydrochloride
  • Short description
    PI3-K inhibitor. Suppresses mESC proliferation.
  • Biological description

    LY 294002 hydrochloride is a competitive and reversible PI3-Kinase inhibitor (IC50 values are 0.5, 0.6, 0.3 and 3.8 µM at p110α (PI3-Kα), p110β (PI3-Kβ), p110δ (PI3-Kδ) and p110γ (PI3-Kγ) respectively). It also shows activity at a range of other PI3-K related kinases and other targets.

    LY 294002 additionally inhibits growth of many tumor types and induces apoptosis. It also suppresses proliferation of mESCs (mouse embryonic stem cells).

  • Alternative names
    TGX-115, PIK-108
  • Biological action
  • Purity
  • Citations


  • Chemical name
    2-(4-Morpholinyl)-8-phenyl-4H-1-ben zopyran-4-one hydrochloride
  • Molecular Weight
  • Chemical structure
    LY 294002 hydrochloride
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for LY 294002 hydrochloride

  • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

    Viahos et al (1994) J Biol Chem 269(7) : 5241-8
    PubMedID: 8106507
  • Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells.

    Lianguzova et al (2007) Cell Biol Int 31(4) : 330-7
    PubMedID: 17321171
  • The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.

    Biommaart et al (1997) Eur J Biochem 243(1-2) : 240-6
    PubMedID: 9030745
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