LY 333531 hydrochloride

(HB0393)

Product overview

  • Name
    LY 333531 hydrochloride
  • Short description
    Potent, selective, competitive PKC inhibitor
  • Biological description
    Potent, selective and competitive protein kinase C (PKC) inhibitor. Selective for PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively) over PKCα by 76- and 61- fold respectively. Shows antinociceptive actions against and improves vascular function in diabetes.
  • Citations

Properties

  • Chemical name
    (9S)-9-[(Dimethylamino)methyl]-6,7, 10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenz o[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecin e-18,20(19H)-dione hydrochloride
  • Molecular Weight
    505.01
  • Chemical structure
    LY 333531 hydrochloride  [169939-93-9]
  • Molecular Formula
    C28H28N4O3.HCl
  • CAS Number
    169939-93-9

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (20mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for LY 333531 hydrochloride

  • (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.

    Jirousek MR et al (1996) J Med Chem 39(14) : 2664-71.
    PubMedID: 8709095
  • Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons.

    Kim H et al (2003) Diabetes 52(8) : 2102-9.
    PubMedID: 12882929
  • Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes.

    Cotter MA et al (2002) Clin Sci (Lond) 103(3) : 311-21.
    PubMedID: 12193157

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