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Product overview

  • Name
  • Short description
    Potent, highly selective mGlu1a antagonist
  • Biological description

    LY367385 is a potent, highly selective and competitive mGlu1a receptor antagonist (IC50 = 8.8 μM for blockade of quis-induced phosphoinositide (PI) hydrolysis, compared with >100μM for mGluR5 mediated responses).

    LY367385 impairs induction and late phases of both long term potentiation (LTP) and long term depression (LTD) when applied before high-frequency tetanization (HFT) or low-frequency stimulation (LFS).

    LY367385 also displays antidepressant, anticonvulsant and neuroprotective actions.

  • Biological action
  • Purity
  • Citations



  • Chemical name
  • Molecular Weight
  • Chemical structure
    LY 367385  [198419-91-9]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    Off-white solid

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in 0.1M NaOH (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for LY367385

  • Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).

    Chapman AG et al (1999) Eur J Pharmacol 368(1) : 17-24.
    PubMedID: 10096765
  • Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept

    Bruno V et al (1999) Neuropharmacology 38(2) : 199-207.
    PubMedID: 10218860
  • Antidepressant-like effects of baclofen and LY367385 in the forced swim test in rats.

    Car H et al (2006) Pharmacol Rep 58(5) : 758-64.
    PubMedID: 17085869
  • Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.

    Neyman et al (2008) Eur J Neurosci 27(6) : 1345-52
    PubMedID: 18364018
Our products in action
The following papers have cited the use of LY367385 (HB0398) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

    Valentinova and Mameli(2016) Cell Rep 16(9) : 2298-307
    PubMedID: 27545888
  • PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

    Sweeny et al (2017) Sci Rep. 7 : 43606
    PubMedID: 28256580
  • Presynaptic mGluR5 receptor controls glutamatergic input through protein kinase C-NMDA receptors in paclitaxel-induced neuropathic pain.

    Xie et al(2017) J Biol Chem pii: jbc.M117.818476. : doi: 10.1074/jbc.M117.818476.
    PubMedID: 29074619
  • Neuronal glutamate transporters control dopaminergic signaling and compulsive behaviors

    Bellini et al(2017) bioRxiv :
  • Mechanisms of synaptic zinc plasticity at mouse dorsal cochlear nucleus glutamatergic synapses

    Tzounopoulos and Vogler(2018) bioRxiv doi :
  • The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

    Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646
    PubMedID: 30590038
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  • Verified customer, Seoul National University

    Very excellent! thanks for always kindness :) Thank you so much.