Product overview

  • Name
    LY367385
  • Short description
    Potent, highly selective mGlu1a antagonist
  • Biological description

    Potent, highly selective and competitive mGlu1a receptor antagonist (IC50 = 8.8 μM for blockade of quis-induced phosphoinositide (PI) hydrolysis, compared with >100μM for mGluR5 mediated responses).

    Impairs induction and late phases of both long term potentiation (LTP) and long term depression (LTD) when applied before high-frequency tetanization (HFT) or low-frequency stimulation (LFS).

    Also displays antidepressant, anticonvulsant and neuroprotective actions.

  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Images

Properties

  • Chemical name
    (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid
  • Molecular Weight
    209.2
  • Chemical structure
    LY 367385  [198419-91-9]
  • Molecular Formula
    C10H11NO4
  • CAS Number
    198419-91-9
  • PubChem identifier
    5311261
  • SMILES
    CC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N
  • Source
    Synthetic
  • InChi
    InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
  • InChiKey
    SGIKDIUCJAUSRD-QMMMGPOBSA-N
  • MDL number
    MFCD02262124
  • Appearance
    Off-white solid

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in 0.1M NaOH (100mM)

References for LY367385

  • Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).

    Chapman AG et al (1999) Eur J Pharmacol 368(1) : 17-24.
    PubMedID: 10096765
  • Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept

    Bruno V et al (1999) Neuropharmacology 38(2) : 199-207.
    PubMedID: 10218860
  • Antidepressant-like effects of baclofen and LY367385 in the forced swim test in rats.

    Car H et al (2006) Pharmacol Rep 58(5) : 758-64.
    PubMedID: 17085869
  • Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.

    Neyman et al (2008) Eur J Neurosci 27(6) : 1345-52
    PubMedID: 18364018
The following papers have cited the use of LY367385 (HB0398) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

    Valentinova and Mameli(2016) Cell Rep 16(9) : 2298-307
    PubMedID: 27545888
  • PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

    Sweeny et al (2017) Sci Rep. 7 : 43606
    PubMedID: 28256580