Margatoxin

(HB1083)

Product overview

  • Name
    Margatoxin
  • Short description
    Potent, non-selective Kv1.3 channel blocker
  • Biological description
    Potent and non-selective Kv1.3 channel blocker (IC50 = approx. 30 pM; Kd = 11.7 pM). Also inhibits Kv1.2 and Kv1.1 channels (Kd values are 6.4 pM and 4.2 nM respectively). Blocks VEGF-induced Ca2+ entry and hyperpolarisation of endothelial cells.
  • Biological action
    Blocker
  • Our products in action

Properties

  • Molecular Weight
    4178.96
  • Molecular Formula
    C178H286N52O50S7
  • CAS Number
    145808-47-5

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in water

References for Margatoxin

  • Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels.

    Bartok A et al (2014) Toxicon 87 : 6-16.
    PubMedID: 24878374
  • Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.

    Garcia-Calvo M et al (1993) J Biol Chem 268(25) : 18866-74.
    PubMedID: 8360176
  • Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells.

    Erdogan A et al (2005) J Vasc Res 42(5) : 368-76.
    PubMedID: 16043967

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