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Product overview

  • Name
    MC 1568
  • Short description
    Selective class IIa HDAC inhibitor
  • Biological description
    Selective class IIa histone deacetylase (HDAC) inhibitor. Inhibits HDAC4 and HDAC5 in the heart and skeletal muscle and suppresses myogenesis. Also inhibits IL-8 expression and promotes neurite growth. Shows neuroprotective, anti-proliferative and anti-cancer actions. Blood-brain barrier permeable.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    3-[5-(3-(3-Fluorophenyl)-3-oxoprope n-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-prope namide
  • Molecular Weight
  • Chemical structure
    MC 1568  [852475-26-4]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MC 1568

  • Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells.

    Venza I et al (2013) Pigment Cell Melanoma Res 26(2) : 193-204.
    PubMedID: 23176534
  • Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult.

    Collins LM et al (2014) Mol Neurobiol :
    PubMedID: 25065734
  • Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.

    Nebbioso A et al (2009) EMBO Rep 10(7) : 776-82.
    PubMedID: 19498465
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