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Product overview

  • Name
  • Short description
    Selective mGlu8 receptor antagonist
  • Biological description
    Selective mGlu8 receptor antagonist (Ki = 2.3 μM in mouse hippocampal slices). Can be used to distinguish actions of DCPG on mGlu8 receptors versus off-target effects on mGlu2 receptors. Also shown to reverse DCPG induced long term depression.
  • Alternative names
  • Citations


  • Chemical name
    (RS)-4-(1-Amino-1-carboxyethyl)phthalic acid
  • Molecular Weight
  • Chemical structure
  • Molecular Formula
  • PubChem identifier
  • InChi
  • InChiKey

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in 0.1M NaOH (100mM) and in DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MDCPG

  • Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.

    Mercier MS et al (2013) Neuropharmacology 67 : 294-303
    PubMedID: 23220400
  • Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors.

    Lodge D et al (2013) Neuropharmacology 74 : 135-46
    PubMedID: 23542080
Our products in action
The following papers have cited the use of MDCPG (HB1602) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Metabotropic Glutamate Receptor 5 and 8 Modulate the Ameliorative Effect of Ultramicronized Palmitoylethanolamide on Cognitive Decline Associated with Neuropathic Pain

    Boccella S et al(2019) Int J Mol Sci 20(7) : E1757
    PubMedID: 30970677
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