Product overview

  • Name
    MDCPG
  • Short description
    Selective mGlu8 receptor antagonist
  • Biological description
    Selective mGlu8 receptor antagonist (Ki = 2.3 μM in mouse hippocampal slices). Can be used to distinguish actions of DCPG on mGlu8 receptors versus off-target effects on mGlu2 receptors. Also shown to reverse DCPG induced long term depression.
  • Alternative names
    (RS)-MDCPG
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Properties

  • Chemical name
    (RS)-4-(1-Amino-1-carboxyethyl)phthalic acid
  • Molecular Weight
    253.06
  • Chemical structure
    MDCPG
  • Molecular Formula
    C11H11NO6
  • PubChem identifier
    91996985
  • SMILES
    CC(C1=CC(=C(C=C1)C(=O)O)C(=O)O)(C(=O)O)N
  • InChi
    InChI=1S/C11H11NO6/c1-11(12,10(17)18)5-2-3-6(8(13)14)7(4-5)9(15)16/h2-4H,12H2,1H3,(H,13,14)(H,15,16)(H,17,18)
  • InChiKey
    IGLGZJSKFBLMKQ-UHFFFAOYSA-N

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in 0.1M NaOH (100mM) and in DMSO

References for MDCPG

  • Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.

    Mercier MS et al (2013) Neuropharmacology 67 : 294-303
    PubMedID: 23220400
  • Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors.

    Lodge D et al (2013) Neuropharmacology 74 : 135-46
    PubMedID: 23542080