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Data

Product overview

  • Name
    MDL 100907
  • Short description
    Potent and selective 5-HT2A receptor antagonist
  • Biological description
    Potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM). Shows > 80-fold selectivity for 5-HT2A over other 5-HT receptor subtypes. Displays antipsychotic actions. Active in vivo.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2 -(4-fluorophenyl)ethyl]-4-piperinemethanol
  • Molecular Weight
    373.46
  • Chemical structure
    MDL 100907 | [139290-65-6]
  • Molecular Formula
    C22H28FNO3
  • CAS Number
    139290-65-6
  • PubChem identifier
    5311271
  • SMILES
    COC1=CC=CC(=C1OC)[C@@H](C2CCN(CC2)CCC3=CC=C(C=C3)F)O
  • Source
    Synthetic
  • InChi
    InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1
  • InChiKey
    HXTGXYRHXAGCFP-OAQYLSRUSA-N
  • MDL number
    MFCD00909060
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100 mM) and in 0.05M HCl (50 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MDL 100907

  • Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.

    Kehne et al (1996) J Pharmacol Exp Ther 277(2) : 968-81
    PubMedID: 8627580
  • The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of dif

    Ardayfio et al (2008) J Pharmacol Exp Ther 327(3) : 891-7
    PubMedID: 18772320
  • Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.

    Sorensen et al (1993) J Pharmacol Exp Ther 266(2) : 684-91
    PubMedID: 8102646
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