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Memantine hydrochloride


Product overview

  • Name
    Memantine hydrochloride
  • Short description
    Non-competitive NMDA receptor antagonist
  • Biological description

    Non-competitive NMDA receptor antagonist (IC50 = 1.25 μM). Binds to ion channel site.

    Shows low affinity but has rapid blocking and unblocking ability at the NMDAR.

    Selectively blocks extrasynaptic NMDARs.

    Enhances hippocampal long-term potentiation (LTP) and reverses LTP suppression.

    Improves cognitive function and shows anti-Alzheimer's activity.

  • Alternative names
    Axura, Akatinol, Namenda, Ebixa, Abixa, Memox
  • Biological action
  • Purity
  • Citations



  • Chemical name
    3,5-Dimethyl-tricyclo[,7]decan-1-amine hydrochloride
  • Molecular Weight
  • Chemical structure
    Memantine hydrochloride  [41100-52-1]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid


  • Application notes

    The voltage sensitive NMDA receptor antagonist memantine is effective at concentrations of 10-100 µM. In CA1 hippocampal neurons held at – 30 Mv, Hello Bio memantine (at 100 µM) gradually inhibited evoked NMDA receptor mediated excitatory currents over time (see Fig 1 above).


    #Protocol 1: Assay evoked NMDAR currents at -30 mV (used for memantine)

    • NMDAR currents were recorded via whole cell voltage clamp recordings of CA1 pyramidal neurons from the rat hippocampal brain slice and evoked via a stimulating electrode placed in the CA3 region to stimulate the Schaffer collateral pathway.
    • Each NMDAR current was evoked via a single square (150 µs) pulse every 10 sec at a stimulus intensity that gave a reliable NMDAR current.
    • Neurons were constantly held at -30 mV and NMDAR currents recorded in response to continual bath applications of NMDAR antagonists.
    • All NMDAR recordings were made in the presence of GABAA-R and AMPA-R antagonists.

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Memantine hydrochloride

  • The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner.

    Rammes G et al (2001) Neurosci Lett 306(1-2) : 81-4.
    PubMedID: 11403963
  • Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data.

    Parsons CG et al (1999) Neuropharmacology 38(6) : 735-67.
    PubMedID: 10465680
  • Memantine binding to a superficial site on NMDA receptors contributes to partial trapping.

    Kotermanski SE et al (2009) J Physiol 587(Pt 19) : 4589-604.
    PubMedID: 19687120
  • Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons.

    Wu and Johnson (2015) Brain Res. 1603 : 1-7
    PubMedID: 25656790
  • Effects of memantine on hippocampal long-term potentiation, gamma activity, and sensorimotor gating in freely moving rats.

    Ma et al (2015) Neurobiol Aging 36(9) : 2544-54
    PubMedID: 26119223
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