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Mepyramine maleate


Product overview

  • Name
    Mepyramine maleate
  • Short description
    Selective H1 receptor inverse agonist
  • Biological description
    Selective H1 receptor inverse agonist. Selective for H1 over H2, H3 and H4 receptors (Ki values are 0.4 nM, 5.2, >10 and >10 µM respectively). Also a potent KCNQ/M potassium channel blocker. Shows anti-allergic and neuroexcitatory actions. Blood-brain barrier permeable.
  • Alternative names
    Pyrilamine maleate
  • Biological action
  • Citations


  • Chemical name
    2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate
  • Molecular Weight
  • Chemical structure
    Mepyramine maleate
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Mepyramine maleate

  • Histamine and its receptors.

    Parsons ME et al (2006) Br J Pharmacol 147 Suppl 1 : S127-35.
    PubMedID: 16402096
  • Transport mechanism of an H1-antagonist at the blood-brain barrier: transport mechanism of mepyramine using the carotid injection technique.

    Yamazaki M et al (1994) Biol Pharm Bull 17(5) : 676-9.
    PubMedID: 7920432
  • Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons.

    Liu B et al (2008) Neuropharmacology 54(4) : 629-39.
    PubMedID: 18222495
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