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Mepyramine maleate

(HB2622)
Data

Product overview

  • Name
    Mepyramine maleate
  • Short description
    Selective H1 receptor inverse agonist
  • Biological description
    Selective H1 receptor inverse agonist. Selective for H1 over H2, H3 and H4 receptors (Ki values are 0.4 nM, 5.2, >10 and >10 µM respectively). Also a potent KCNQ/M potassium channel blocker. Shows anti-allergic and neuroexcitatory actions. Blood-brain barrier permeable.
  • Alternative names
    Pyrilamine maleate
  • Biological action
    Agonist
  • Citations

Properties

  • Chemical name
    2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate
  • Molecular Weight
    401.46
  • Chemical structure
    Mepyramine maleate
  • Molecular Formula
    C17H23N3O.C4H4O4
  • CAS Number
    59-33-6
  • PubChem identifier
    5284451
  • SMILES
    CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
  • InChi
    InChI=1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
  • InChiKey
    JXYWFNAQESKDNC-BTJKTKAUSA-N
  • MDL number
    MFCD00069333
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100 mM) and in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Mepyramine maleate

  • Histamine and its receptors.

    Parsons ME et al (2006) Br J Pharmacol 147 Suppl 1 : S127-35.
    PubMedID: 16402096
  • Transport mechanism of an H1-antagonist at the blood-brain barrier: transport mechanism of mepyramine using the carotid injection technique.

    Yamazaki M et al (1994) Biol Pharm Bull 17(5) : 676-9.
    PubMedID: 7920432
  • Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons.

    Liu B et al (2008) Neuropharmacology 54(4) : 629-39.
    PubMedID: 18222495
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