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Metformin hydrochloride

(HB2153)
Data

Product overview

  • Name
    Metformin hydrochloride
  • Short description
    LKB1/AMPK activator. Also promotes neurogenesis.
  • Biological description
    LKB1/AMPK activator. Blood brain barrier permeable. Improves insulin sensitivity and decreases plasma glucose levels to show antidiabetic activity. Also inhibits cancer stem cells (CSCs) and shows anticancer and anti-neoplastic effects. Promotes neurogenesis by activating the PKC-CBP pathway.
  • Biological action
    Activator
  • Citations

Properties

  • Chemical name
    N,N-Dimethylimidodicarbonimidic diamide hydrochloride
  • Molecular Weight
    165.62
  • Chemical structure
    Metformin hydrochloride |  [1115-70-4]
  • Molecular Formula
    C4H11N5.HCl
  • CAS Number
    1115-70-4

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in water (100mM) or DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Metformin hydrochloride

  • AMP-activated protein kinase in metabolic control and insulin signaling.

    Towler and Hardie (2007) Circ Res 100(3) : 32841
    PubMedID: 17307971
  • Metformin, cancer and glucose metabolism.

    Salani et al (2014) Endocr Relat Cancer 21(6) : 461-71
    PubMedID: 25273809
  • Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.

    Wang et al (2012) Cell Stem Cell 11(1) : 23-35
    PubMedID: 22770240
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