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Data

Product overview

  • Name
    MG132
  • Short description
    Potent, cell-permeable proteasome inhibitor. Calpain inhibitor.
  • Biological description
    Potent, cell-permeable proteasome inhibitor (IC50 = 100 nM). Blocks the proteolytic activity of the 26S proteasome complex. Induces cell cycle arrest and triggers apoptosis to inhibit cell growth. Shows anti-cancer activity in vivo. Also calpain inhibitor.
  • Alternative names
    Z-LLL-al, Z-Leu-Leu-Leu-CHO
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
  • Molecular Weight
    475.62
  • Chemical structure
    MG-132 (Z-Leu-Leu-Leu-CHO|Z-LLL-al) [133407-82-6 ]
  • Molecular Formula
    C26H41N3O5
  • CAS Number
    133407-82-6
  • PubChem identifier
    462382
  • SMILES
    CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
  • Source
    Synthetic
  • InChi
    InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
  • InChiKey
    TZYWCYJVHRLUCT-VABKMULXSA-N
  • MDL number
    MFCD00674886

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MG132

  • The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH.

    Han et al (2009) Oncol Rep 22(1) : 215-21
    PubMedID: 19513526
  • Potential of the proteasomal inhibitor MG-132 as an anticancer agent, alone and in combination.

    Banerjeet and Liefshitz (2001) Anticancer Res 3941-7 : 21(6A)
    PubMedID: 11911275
  • Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine.

    Tsubuki et al (1996) J Biochem 119(3) : 572-6
    PubMedID: 8830056
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