In my cart

You have no items in your shopping cart.

Mifepristone

(HB2783)
Data

Product overview

  • Name
    Mifepristone
  • Short description
    Potent glucocorticoid and progesterone receptor antagonist
  • Biological description
    Potent glucocorticoid (GR) and progesterone receptor (PR) antagonist (EC50 values are 2, 10.6 and 9.5 nM at GR, PR-A and PR-B respectively). Also weakly binds the androgen receptor. Shows higher affinity for PRs than progesterone. Shows neuroprotective and antitumor effects. Active in vivo.
  • Alternative names
    RU486 | RU38486
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one
  • Molecular Weight
    429.6
  • Chemical structure
    Mifepristone
  • Molecular Formula
    C29H35NO2
  • CAS Number
    84371-65-3

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Mifepristone

  • Mifepristone prevents stress-induced apoptosis in newborn neurons and increases AMPA receptor expression in the dentate gyrus of C57/BL6 mice.

    Llorens-Martã?n M et al (2011) PLoS One 6(11) : e28376.
    PubMedID: 22140582
  • The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature.

    Yuan H et al (2012) Cancer Prev Res (Phila) 5(5) : 754-64.
    PubMedID: 22427346
  • Novel protective effect of mifepristone on detrimental GABAA receptor activity to immature Purkinje neurons.

    Rakotomamonjy J et al (2011) FASEB J 25(11) : 3999-4010.
    PubMedID: 21795502
  • Binding of the anti-progestin RU-486 to rat ovary steroid receptors.

    Schreiber JR et al (1983) Contraception 28(1) : 77-85.
    PubMedID: 6627946
Support & Resources

Reviews & Product Guides