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Product overview

  • Name
  • Short description
    Potent glucocorticoid and progesterone receptor antagonist
  • Biological description
    Potent glucocorticoid (GR) and progesterone receptor (PR) antagonist (EC50 values are 2, 10.6 and 9.5 nM at GR, PR-A and PR-B respectively). Also weakly binds the androgen receptor. Shows higher affinity for PRs than progesterone. Shows neuroprotective and antitumor effects. Active in vivo.
  • Alternative names
    RU486 | RU38486
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Mifepristone

  • Mifepristone prevents stress-induced apoptosis in newborn neurons and increases AMPA receptor expression in the dentate gyrus of C57/BL6 mice.

    Llorens-Martã?n M et al (2011) PLoS One 6(11) : e28376.
    PubMedID: 22140582
  • The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature.

    Yuan H et al (2012) Cancer Prev Res (Phila) 5(5) : 754-64.
    PubMedID: 22427346
  • Novel protective effect of mifepristone on detrimental GABAA receptor activity to immature Purkinje neurons.

    Rakotomamonjy J et al (2011) FASEB J 25(11) : 3999-4010.
    PubMedID: 21795502
  • Binding of the anti-progestin RU-486 to rat ovary steroid receptors.

    Schreiber JR et al (1983) Contraception 28(1) : 77-85.
    PubMedID: 6627946
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