Miltefosine

(HB0412)

Product overview

  • Name
    Miltefosine
  • Short description
    Akt inhibitor
  • Biological description
    Akt inhibitor. Inhibits T-cell proliferation and HIV-1 cell survival and production. Displays anti-inflammatory and anticancer properties with broad spectrum of fungicidal and antiamoebae activities. Blood brain barrier permeable.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1-Hexadecylphosphorylcholine
  • Molecular Weight
    407.6
  • Chemical structure
    Miltefosine  [58066-85-6]
  • Molecular Formula
    C21H46NO4P
  • CAS Number
    58066-85-6
  • PubChem identifier
    3599
  • SMILES
    CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C

Storing and Using Your Product

  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Miltefosine

  • Miltefosine suppresses inflammation in a mouse model of inflammatory bowel disease.

    Verhaar AP et al (2013) Inflamm Bowel Dis 19(9) : 1974-82.
    PubMedID: 23811637
  • Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.

    Chugh P et al (2008) Retrovirology 5 : 11
    PubMedID: 18237430
  • Miltefosine enhances phagocytosis but decreases nitric oxide production by peritoneal macrophages of C57BL/6 mice.

    Ponte CB et al (2012) Int Immunopharmacol 13(1) : 114-9.
    PubMedID: 22465961

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