Product overview

  • Name
    ML 213
  • Short description
    Selective Kv7.2 / Kv7.4 channel activator
  • Biological description
    Selective Kv7.2 and Kv7.4 channel activator (EC50 values are 230 and 510 nM respectively). Exhibits >80-fold selectivity for Kv7.2 and Kv7.4 channels over other K+ channels. Displays vasorelaxant properties.
  • Biological action
    Activator
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N-(2,4,6-Trimethylphenyl)-bicyclo[2 .2.1]heptane-2-carboxamide
  • Molecular Weight
    257.37
  • Chemical structure
    ML 213  [489402-47-3]
  • Molecular Formula
    C17H23NO
  • CAS Number
    489402-47-3

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (50mM) or ethanol (50mM)

References for ML 213

  • Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.

    Yu H et al (2011) ACS Chem Neurosci 2(10) : 572-577.
    PubMedID: 22125664
  • Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370.

    Jepps TA et al (2014) Br J Pharmacol 171(19) : 4413-24.
    PubMedID: 24909207
  • Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.

    Brueggemann LI et al (2014) Mol Pharmacol 86(3) : 330-41.
    PubMedID: 24944189

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