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Biological Data

Biological description Selective Kv7.2 and Kv7.4 channel activator (EC50 values are 230 and 510 nM respectively). Exhibits >80-fold selectivity for Kv7.2 and Kv7.4 channels over other K+ channels. Displays vasorelaxant properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (50mM) or ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name N-(2,4,6-Trimethylphenyl)-bicyclo[2 .2.1]heptane-2-carboxamide
Molecular Weight 257.37
Chemical structure ML 213  [489402-47-3] Chemical Structure
Molecular Formula C17H23NO
CAS Number 489402-47-3
PubChem identifier 3111211
SMILES O=C(NC3=C(C)C=C(C)C=C3C)C1CC2CCC1C2
InChiKey SIQGKPGBLYKQBB-UHFFFAOYSA-N

References for ML 213

References are publications that support the biological activity of the product
  • Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370.

    Jepps TA et al (2014) Br J Pharmacol 171(19) : 4413-24.
  • Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.

    Brueggemann LI et al (2014) Mol Pharmacol 86(3) : 330-41.
  • Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.

    Yu H et al (2011) ACS Chem Neurosci 2(10) : 572-577.

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