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Product overview

  • Name
    ML 289
  • Short description
    Selective mGlu3 negative allosteric modulator
  • Biological description
    Selective mGlu3 receptor negative allosteric modulator (IC50 = 0.66 µM). Displays 15-fold selectivity over mGlu2 receptor and is inactive against mGlu5 receptor. Blood-brain barrier permeable.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    ML 289  [1382481-79-9]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ML 289

  • Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.

    Sheffler DJ et al (2012) Bioorg Med Chem Lett 22(12) : 3921-5.
    PubMedID: 22607673
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