ML 289

(HB0414)

Product overview

  • Name
    ML 289
  • Short description
    Selective mGlu3 negative allosteric modulator
  • Biological description
    Selective mGlu3 receptor negative allosteric modulator (IC50 = 0.66 µM). Displays 15-fold selectivity over mGlu2 receptor and is inactive against mGlu5 receptor. Blood-brain barrier permeable.
  • Biological action
    NAM
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    [(3R)-3-(Hydroxymethyl)-1-pipridinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanone
  • Molecular Weight
    349.42
  • Chemical structure
    ML 289  [1382481-79-9]
  • Molecular Formula
    C22H23NO3
  • CAS Number
    1382481-79-9

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ML 289

  • Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.

    Sheffler DJ et al (2012) Bioorg Med Chem Lett 22(12) : 3921-5.
    PubMedID: 22607673