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ML-7 hydrochloride


Product overview

  • Name
    ML-7 hydrochloride
  • Short description
    Selective MLCK inhibitor
  • Biological description
    Selective myosin light chain kinase (MLCK) inhibitor (Ki = 0.3 µM). Shows reversible ATP- competitive inhibition of Ca2+ calmodulin independent/ dependant smooth muscle MLCK. Approx 10-fold more potent inhibitor than ML-9 Shows antiglaucomatous actions.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
  • Molecular Weight
  • Chemical structure
    ML-7  [110448-33-4]
  • Molecular Formula
  • CAS Number
  • PubChem identifier

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ML-7 hydrochloride

  • Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.

    Saitoh M et al (1987) J Biol Chem 262(16) : 7796-801.
    PubMedID: 3108259
  • The specificities of protein kinase inhibitors: an update.

    Bain J et al (2003) Biochem J 371(Pt 1) : 199-204.
    PubMedID: 12534346
  • Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork.

    Rosenthal R et al (2005) Exp Eye Res 80(6) : 837-45.
    PubMedID: 15939040
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