MPEP hydrochloride

(HB0426)

Product overview

  • Name
    MPEP hydrochloride
  • Short description
    Potent, selective mGlu5 antagonist / mGlu4 positive allosteric modulator
  • Biological description

    Potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 36 nM). Also a mGlu4 receptor positive allosteric modulator.

    Prevents induction of various types of long term potentiation (LTP) and long term depression (LTD).

    Suppresses addiction-like behaviour for cocaine, ethanol and nicotine in various models of addiction. Blood-brain barrier permeable. Active in vivo.

    Water soluble MTEP hydrochloride also available.

  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Images

Properties

  • Chemical name
    2-Methyl-6-(phenylethynyl)pyridine hydrochloride
  • Molecular Weight
    229.71
  • Chemical structure
    MPEP hydrochloride  [219911-35-0]
  • Molecular Formula
    C14H11N.HCl
  • CAS Number
    219911-35-0
  • PubChem identifier
    9794588
  • SMILES
    CC1=CC=CC(=N1)C#CC2=CC=CC=C2.Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
  • InChiKey
    PKDHDJBNEKXCBI-UHFFFAOYSA-N
  • MDL number
    MFCD02262119
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MPEP hydrochloride

  • 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.

    Gasparini F et al (1999) Neuropharmacology 38(10) : 1493-503.
    PubMedID: 10530811
  • Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.

    Latif-Hernandez et al (2016) Front Cell Neurosci. 7; : 10:252
    PubMedID: 27872582
  • NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression.

    Izumi and Zorumski (2012) Neuropsychopharmacology 37(3) : 609-17
    PubMedID: 21993209
  • Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.

    Mihov and Hasler (2016) Int J Neuropsychopharmacol. 5; : 19(7)
    PubMedID: 26802568
The following papers have cited the use of MPEP hydrochloride (HB0426) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

    Sweeny et al (2017) Sci Rep. 7 : 43606
    PubMedID: 28256580