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MPEP hydrochloride


Product overview

  • Name
    MPEP hydrochloride
  • Short description
    Potent, selective mGluR5 antagonist / mGluR4 positive allosteric modulator
  • Biological description

    MPEP hydrochloride is a potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 36 nM) and also a mGlu4 receptor positive allosteric modulator (PAM).

    MPEP prevents induction of various types of long term potentiation (LTP) and long term depression (LTD).

    MPEP also suppresses addiction-like behaviour for cocaine, ethanol and nicotine in various models of addiction. MPEP is blood-brain barrier (BBB) permeable and is active in vivo.

    Water soluble MTEP hydrochloride is also available.

  • Biological action
  • Purity
  • Citations



  • Chemical name
    2-Methyl-6-(phenylethynyl)pyridine hydrochloride
  • Molecular Weight
  • Chemical structure
    MPEP hydrochloride  [219911-35-0]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MPEP hydrochloride

  • 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.

    Gasparini F et al (1999) Neuropharmacology 38(10) : 1493-503.
    PubMedID: 10530811
  • Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.

    Latif-Hernandez et al (2016) Front Cell Neurosci. 7; : 10:252
    PubMedID: 27872582
  • NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression.

    Izumi and Zorumski (2012) Neuropsychopharmacology 37(3) : 609-17
    PubMedID: 21993209
  • Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.

    Mihov and Hasler (2016) Int J Neuropsychopharmacol. 5; : 19(7)
    PubMedID: 26802568
Our products in action
The following papers have cited the use of MPEP hydrochloride (HB0426) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

    Sweeny et al (2017) Sci Rep. 7 : 43606
    PubMedID: 28256580
  • Neuronal glutamate transporters control dopaminergic signaling and compulsive behaviors

    Bellini et al(2017) bioRxiv :
  • Mechanisms of synaptic zinc plasticity at mouse dorsal cochlear nucleus glutamatergic synapses

    Tzounopoulos and Vogler(2018) bioRxiv doi :
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