Product overview

  • Name
    MS 436
  • Short description
    Potent, selective BRD4 bromodomain inhibitor
  • Biological description
    Potent and selective BRD4 bromodomain inhibitor (Ki = 30-50 nM). Selective for the first over the second bromodomain. Inhibits the activity of BRD4 in macrophage nitric oxide and Il-6 production. Alters colony integrity in embryonic stem cells. Shows antiproliferative and anticancer actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
  • Molecular Weight
    383.42
  • Chemical structure
    MS 436   [1395084-25-9]
  • Molecular Formula
    C18H17N5O3S
  • CAS Number
    1395084-25-9

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (100mM)

References for MS 436

  • BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy.

    Segura MF et al (2013) Cancer Res 73(20) : 6264-76.
    PubMedID: 23950209
  • Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains.

    Zhang G et al (2013) J Med Chem 56(22) : 9251-64.
    PubMedID: 24144283
  • Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes.

    Di Micco R et al (2014) Cell Rep 9(1) : 234-47.
    PubMedID: 25263550

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