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Product overview

  • Name
    MS 436
  • Short description
    Potent, selective BRD4 bromodomain inhibitor
  • Biological description
    Potent and selective BRD4 bromodomain inhibitor (Ki = 30-50 nM). Selective for the first over the second bromodomain. Inhibits the activity of BRD4 in macrophage nitric oxide and Il-6 production. Alters colony integrity in embryonic stem cells. Shows antiproliferative and anticancer actions.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    MS 436   [1395084-25-9]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MS 436

  • BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy.

    Segura MF et al (2013) Cancer Res 73(20) : 6264-76.
    PubMedID: 23950209
  • Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains.

    Zhang G et al (2013) J Med Chem 56(22) : 9251-64.
    PubMedID: 24144283
  • Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes.

    Di Micco R et al (2014) Cell Rep 9(1) : 234-47.
    PubMedID: 25263550
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