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N-Arachidonyl-L-alanine

(HB0440)
Data

Product overview

  • Name
    N-Arachidonyl-L-alanine
  • Short description
    GLYT2 / GLYT2(EL2) inhibitor
  • Biological description
    GLYT2 and GLYT2(EL2) inhibitor (IC30 values are 5.9 and 6.0 µM). Displays little or no activity at GLYT1 (IC30 = >30 µM). Inhibits pain.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    2-(Icosa-5,8,11,14-tetraenoylamino)propanoic acid
  • Molecular Weight
    375.6
  • Chemical structure
    N-Arachidonyl-L-alanine  [401941-73-9]
  • Molecular Formula
    C23H37NO3
  • CAS Number
    401941-73-9
  • PubChem identifier
    53394356
  • SMILES
    C[C@@H](NC(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)C(=O)O

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in DMSO (50mM) or ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for N-Arachidonyl-L-alanine

  • Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.

    Edington AR et al (2009) J Biol Chem 284(52) : 36424-30.
    PubMedID: 19875446
  • Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.

    Huang SM et al (2001) J Biol Chem 276(46) : 42639-44.
    PubMedID: 11518719
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