N-Arachidonylglycine (NAGly)

(HB0439)

Product overview

  • Name
    N-Arachidonylglycine (NAGly)
  • Short description
    Endogenous GLYT2 inhibitor / Cav3.1 / 3.2 / 3.3 current inhibitor
  • Biological description
    Endogenous GLYT2 inhibitor (IC50 = 3 µM) that displays little activity at GLYT1. Also reversibly inhibits Cav3.1, Cav3.2 and Cav3.3 currents (EC50 values are 1.3 µM, 600 nM and 1.6 µM respectively). Novel insulin secretagogue and natural ligand for orphan G-protein-coupled receptor, GPR18. Displays analgesic properties.
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetrae nyl)glycine
  • Molecular Weight
    361.52
  • Chemical structure
    N-Arachidonylglycine (NAGly)  [179113-91-8]
  • Molecular Formula
    C22H35NO3
  • CAS Number
    179113-91-8
  • PubChem identifier
    5283389
  • SMILES
    O=C(CCC/C=CC/C=CC/C=CC/C=CCCCCC)NCC(=O)O

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for N-Arachidonylglycine (NAGly)

  • Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.

    Ikeda Y et al (2005) Biochem Biophys Res Commun 333(3) : 778-86.
    PubMedID: 15967412
  • Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.

    Kohno M et al (2006) Biochem Biophys Res Commun 347(3) : 827-32.
    PubMedID: 16844083
  • T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.

    Barbara G et al (2009) J Neurosci 29(42) : 13106-14.
    PubMedID: 19846698
  • Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.

    Edington AR et al (2009) J Biol Chem 284(52) : 36424-30.
    PubMedID: 19875446

Reviews & Product Guides