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Naloxone hydrochloride

(HB2451)
Data

Product overview

  • Name
    Naloxone hydrochloride
  • Short description
    Competitive opioid receptor antagonist
  • Biological description

    Competitive opioid receptor antagonist with high affinity at µ-opioid receptors. Blocks effects of opiods. Induces acute withdrawal state in opiate-dependent models.

    Active in vivo.

  • Alternative names
    NLX
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (5α)-4,5-Epoxy-3,14-dihydro-17-(2-pr openyl)morphinan-6-one hydrochloride
  • Molecular Weight
    363.84
  • Chemical structure
    Naloxone hydrochloride
  • Molecular Formula
    C19H21NO4.HCl
  • CAS Number
    357-08-4
  • PubChem identifier
    5464092
  • SMILES
    C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
  • InChi
    InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1
  • InChiKey
    RGPDIGOSVORSAK-STHHAXOLSA-N
  • MDL number
    MFCD00150901
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Naloxone hydrochloride

  • Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.

    Spivak et al (1997) Mol Pharmacol 52(6) : 983-92
    PubMedID: 9415708
  • Error correction in latent inhibition and its disruption by opioid receptor blockade with naloxone.

    Leung et al (2013) Neuropsychopharmacology 38(12) : 2439-45
    PubMedID: 23748224
  • Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine.

    Pinelli et al (1997) J Pharmacol Toxicol Methods 38(3) : 117-31
    PubMedID: 9523765
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