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Naltrexone hydrochloride

(HB2452)
Data

Product overview

  • Name
    Naltrexone hydrochloride
  • Short description
    Competitive opioid receptor antagonist
  • Biological description
    Competitive opioid receptor antagonist (Ki values are 1.55, 7.84 and 0.71 nM at µ, δ and κ receptors respectively). Diminishes alcohol reward and motivation and decreases alcohol drinking. Active in vivo.
  • Alternative names
    NTX
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (5α)-17-(Cyclopropylmethyl)-4,5-epox y-3,14-dihydromorphinan-6-one hydrochloride
  • Molecular Weight
    377.87
  • Chemical structure
    Naltrexone hydrochloride
  • Molecular Formula
    C20H23NO4.HCl
  • CAS Number
    16676-29-2
  • PubChem identifier
    5485201
  • SMILES
    C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O.Cl
  • InChi
    InChI=1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
  • InChiKey
    RHBRMCOKKKZVRY-ITLPAZOVSA-N
  • MDL number
    MFCD00069324
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Our products in action
The following papers have cited the use of Naltrexone hydrochloride (HB2452) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Synaptic regulation by OPRM1 variants in reward neurocircuitry.

    Popova et al (2019) J Neurosci : 2317-18
    PubMedID: 31109961
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