Naspm trihydrochloride

(HB0441)

Product overview

  • Name
    Naspm trihydrochloride
  • Short description
    Selective GluA2- lacking, Ca2+ permeable AMPA / kainate receptor antagonist
  • Biological description
    Selective GluA2- lacking, Ca2+ permeable AMPA/kainate receptor antagonist. Synthetic analogue of Joro spider toxin. Reduces excitatory post synaptic currents in infralimbic neurons.
  • Biological action
    Antagonist
  • Purity
    >97%
  • Citations

Properties

  • Chemical name
    N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
  • Molecular Weight
    479.91
  • Chemical structure
    Naspm trihydrochloride  [1049731-36-3]
  • Molecular Formula
    C22H34N4O.3HCl
  • CAS Number
    1049731-36-3
  • PubChem identifier
    16219727
  • SMILES
    C1=CC=C2C(=C1)C=CC=C2CC(=O)NCCCNCCCCNCCCN.Cl.Cl.Cl
  • InChi
    InChI=1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H
  • InChiKey
    JNEOJAUJWOPWJS-UHFFFAOYSA-N
  • MDL number
    MFCD01321052

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Naspm trihydrochloride

  • Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons.

    Koike M et al (1997) Neurosci Res 29(1) : 27-36.
    PubMedID: 9293490
  • ABA renewal involves enhancements in both GluA2-lacking AMPA receptor activity and GluA1 phosphorylation in the lateral amygdala.

    Park K et al (2014) PLoS One 9(6) : e100108.
    PubMedID: 24925360
  • Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons.

    Sepulveda-Orengo MT et al (2013) J Neurosci 33(17) : 7184-93.
    PubMedID: 23616528