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Naspm trihydrochloride


Product overview

  • Name
    Naspm trihydrochloride
  • Short description
    Selective GluA2- lacking, Ca2+ permeable AMPA / kainate receptor antagonist
  • Biological description
    Selective GluA2- lacking, Ca2+ permeable AMPA/kainate receptor antagonist. Synthetic analogue of Joro spider toxin. Reduces excitatory post synaptic currents in infralimbic neurons.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
  • Molecular Weight
  • Chemical structure
    Naspm trihydrochloride  [1049731-36-3]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Naspm trihydrochloride

  • Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons.

    Koike M et al (1997) Neurosci Res 29(1) : 27-36.
    PubMedID: 9293490
  • ABA renewal involves enhancements in both GluA2-lacking AMPA receptor activity and GluA1 phosphorylation in the lateral amygdala.

    Park K et al (2014) PLoS One 9(6) : e100108.
    PubMedID: 24925360
  • Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons.

    Sepulveda-Orengo MT et al (2013) J Neurosci 33(17) : 7184-93.
    PubMedID: 23616528
Our products in action
The following papers have cited the use of Naspm trihydrochloride (HB0441) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Labile Calcium-Permeable AMPA Receptors Constitute New Glutamate Synapses Formed in Hypothalamic Neuroendocrine Cells During Salt Loading

    Di S et al(2019) eNeuro : 0112-19
    PubMedID: 31300543
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