In my cart

You have no items in your shopping cart.

NBQX disodium salt


Product overview

  • Name
    NBQX disodium salt
  • Short description
    Potent, selective, competitive AMPA receptor antagonist. Disodium salt.
  • Biological description

    Potent, selective and competitive AMPA receptor antagonist. Also kainate receptor antagonist. Water soluble, disodium salt. Shows neuroprotective, antinociceptive and anticonvulsive actions. NBQX also available.

  • Biological action
  • Purity
  • Customer comments

    High quality and affordable! We use this compound routinely in the lab for neuronal recordings. Verified customer, The University of Montana

    Worked just as it should, results indistinguishable from our previous product but at a significant cost reduction! Verified customer, The University of Toronto

    Good quality and great price! Verified customer, The University of Newcastle

    NBQX disodium salt produced by Hello Bio produced a very potent and "clean" block of synaptic AMPA currents, with no effect on other GABAA or NMDA receptors.Verified customer, The University of Edinburgh

  • Citations



  • Chemical name
    2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt
  • Molecular Weight
  • Chemical structure
    NBQX disodium salt  [479347-86-9]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    Orange solid


  • Application notes

    The AMPA receptor antagonist NBQX disodium salt inhibits the actions of glutamate by acting at AMPARs and is commonly used at 10 μM. NBQX disodium salt from Hello Bio inhibits spontaneous and evoked excitatory post synaptic currents (EPSCs) (see Fig 1 above). Complete AMPA receptor blockade was achieved at 10 μM and NBQX disodium salt was also effective at reducing these currents at 1 μM. 


    #Protocol 1: Evoked and spontaneous excitatory post synaptic currents (EPSCs)

    • Whole cell voltage clamp recordings were obtained from layer V neurons of the mouse prelimbic cortex brain slice.
    •  EPSCs were evoked via a stimulating electrode placed in layers II/III delivering a single square (150 μs) pulse every 10 sec at an intensity that gave a reliable EPSC.
    • Neurons were held at -70 to -60 mV (the reversal potential of GABA currents). EPSCs were continuously stimulated and recorded in response to 5 min applications of varying concentrations of NBQX disodium salt until complete receptor inhibition.
    • Spontaneous EPSCs were recorded before and after addition of NBQX disodium salt by holding the neuron at -70 mV and recording for 10 sec.
    • Recordings for EPSCs were made in the absence of GABAA-R antagonists.

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NBQX disodium salt

  • It is AMPA receptor, not kainate receptor, that contributes to the NBQX-induced antinociception in the spinal cord of rats.

    Kong LL et al (2006) Brain Res 1100(1) : 73-7.
    PubMedID: 16777075
  • Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro substitution.

    Randle JC et al (1992) Eur J Pharmacol 215(2-3) : 237-44.
    PubMedID: 1382998
  • Both MK801 and NBQX reduce the neuronal damage after impact-acceleration brain injury.

    Goda M et al (2002) J Neurotrauma 19(11) : 1445-56.
    PubMedID: 12490009
  • Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy.

    Namba T et al (1994) Brain Res 638(1-2) : 36-44.
    PubMedID: 8199874
  • Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.

    Alt et al (2004) Neuropharmacology 46(6) : 793-806
    PubMedID: 15033339
Our products in action
The following papers have cited the use of NBQX disodium salt (HB0443) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Impact of the receptor tyrosine kinase EphB2 on cerebral ischemia in mice

    Ernst, AS(2018) Ruperto Carola University Heidelberg : Thesis
  • Pyramidal cell activity levels affect the polarity of gene transciption changes in interneurons.

    Parrish et al(2018) J Neurophysiol doi: 10.1152 : /jn.00287.2018.
    PubMedID: 30110232
  • KCC2 regulates neuronal excitability and hippocampal activity via interaction with Task-3 channels

    Poncer et al (2018) bioRxiv doi: :
  • A Novel Class of Inferior Colliculus Principal Neurons Labeled in Vasoactive Intestinal Peptide-Cre Mice

    Goyer et al (2018) bioRxiv : doi:
  • Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses.

    Trusel et al (2019) Neuron [Epub ahead of print] : pii: S0896-6273(19)30052-2
    PubMedID: 30765165
  • Somatostatin-Expressing Interneurons Co-Release GABA and Glutamate onto Different Postsynaptic Targets in the Striatum.

    Cattaneo et al (2019) bioRxiv :
  • Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release.

    López-Murcia(2521-2530) Cell Rep. : 26(1)
    PubMedID: 30840877
  • Opposite responses to aversive stimuli in lateral habenula neurons.

    Congiu et al (2019) Eur J Neurosci. : doi: 10.1111/ejn.14400. [Epub ah
    PubMedID: 30860301
  • An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons

    Rhee HJ et al(2019) Cell Rep 27(7) : 2212-2228.e7
    PubMedID: 31091457
  • Beyond the suprachiasmatic nucleus: circadian rhythmicity shapes astrocyte morphology and neuronal function in hippocampal area CA1

    Scimemi et al (2019) bioRxiv : 10.1101/666073
Support & Resources


  • Verified customer

    Great compound! We use NBQX in our external recordings solutions for slice electrophysiology to block AMPA receptors. This is a great water soluble option for NBQX.
  • Verified customer

    Reasonable price and it works as it should.
  • Verified customer, UC Denver

    Good product, great price. Works as it should.
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5