Niclosamide

(HB1435)

Product overview

  • Name
    Niclosamide
  • Short description
    STAT3 signaling pathway inhibitor. Antineoplastic against AML stem cells.
  • Biological description
    STAT3 signaling pathway inhibitor and also inhibits mTORC and Wnt/β-catenin pathways. Antineoplastic against AML stem cells. Shows antiproliferative, anticancer, antidiabetic and anthelmintic actions.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    5-Chloro-N-(2-chloro-4-nitrophenyl) -2-hydroxybenzamide
  • Molecular Weight
    325.99
  • Chemical structure
    Niclosamide |  [50-65-7]
  • Molecular Formula
    C13H8Cl2N2O4
  • CAS Number
    50-65-7
  • PubChem identifier
    4477
  • SMILES
    C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
  • InChi
    InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
  • InChiKey
    RJMUSRYZPJIFPJ-UHFFFAOYSA-N
  • MDL number
    MFCD00057597

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (10mM) and in ethanol (10mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Niclosamide

  • Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway.

    Ren X et al (2010) ACS Med Chem Lett 1(9) : 454-9.
    PubMedID: 24900231
  • Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice.

    Tao H et al (2014) Nat Med 20(11) : 1263-9.
    PubMedID: 25282357
  • Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.

    Balgi AD et al (2009) PLoS One 4(9) : e7124.
    PubMedID: 19771169