Pack	Price	Qty
100mg	$59

Nifedipine

(HB1228)

Product overview

Name
Nifedipine
Short description
L-type Ca²⁺ channel blocker
Biological description
L-type Ca²⁺ channel blocker. Causes down regulation of NF-κB, proinflammatory cytokines and cell adhesion molecules. Reduces oxidative stress and smooth muscle cell proliferation and shows potential actions against atherosclerosis. Shows neuroprotective actions for dopaminergic neurones and acts as a vasodilator.
Biological action
Blocker
Purity
>98%
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Chemical name
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddimethylester
Molecular Weight
346.34
Chemical structure
Molecular Formula
C₁₇H₁₈N₂O₆
CAS Number
21829-25-4

Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses.
Daschil N et al (2014) Brain Res 1581 : 1-11.
PubMedID: 25038562
Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB.
S K S S et al (2012) Respir Physiol Neurobiol 183(1) : 26-34.
PubMedID: 22627105
Nifedipine inhibits vascular smooth muscle cell proliferation and reactive oxygen species production through AMP-activated protein kinase signaling pathway.
Sung JY et al (2012) Vascul Pharmacol 56(1-2) : 1-8.
PubMedID: 21708289