Pack	Price	Qty
100mg	$59

Nifedipine

(HB1228)

Product overview

Name
Nifedipine
Short description
L-type Ca²⁺ channel blocker
Biological description
L-type Ca²⁺ channel blocker. Causes down regulation of NF-κB, proinflammatory cytokines and cell adhesion molecules. Reduces oxidative stress and smooth muscle cell proliferation and shows potential actions against atherosclerosis. Shows neuroprotective actions for dopaminergic neurones and acts as a vasodilator.
Biological action
Blocker
Purity
>98%
Citations
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Chemical name
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddimethylester
Molecular Weight
346.34
Chemical structure
Molecular Formula
C₁₇H₁₈N₂O₆
CAS Number
21829-25-4

Storage instructions
+4°C (desiccate)
Solubility overview
soluble in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses.
Daschil N et al (2014) Brain Res 1581 : 1-11.
PubMedID: 25038562
Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB.
S K S S et al (2012) Respir Physiol Neurobiol 183(1) : 26-34.
PubMedID: 22627105
Nifedipine inhibits vascular smooth muscle cell proliferation and reactive oxygen species production through AMP-activated protein kinase signaling pathway.
Sung JY et al (2012) Vascul Pharmacol 56(1-2) : 1-8.
PubMedID: 21708289