Nifedipine

(HB1228)

Product overview

  • Name
    Nifedipine
  • Short description
    L-type Ca2+ channel blocker
  • Biological description
    L-type Ca2+ channel blocker. Causes down regulation of NF-κB, proinflammatory cytokines and cell adhesion molecules. Reduces oxidative stress and smooth muscle cell proliferation and shows potential actions against atherosclerosis. Shows neuroprotective actions for dopaminergic neurones and acts as a vasodilator.
  • Biological action
    Blocker
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddimethylester
  • Molecular Weight
    346.34
  • Chemical structure
    Nifedipine  [21829-25-4]
  • Molecular Formula
    C17H18N2O6
  • CAS Number
    21829-25-4

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in DMSO (100mM)

References for Nifedipine

  • Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses.

    Daschil N et al (2014) Brain Res 1581 : 1-11.
    PubMedID: 25038562
  • Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB.

    S K S S et al (2012) Respir Physiol Neurobiol 183(1) : 26-34.
    PubMedID: 22627105
  • Nifedipine inhibits vascular smooth muscle cell proliferation and reactive oxygen species production through AMP-activated protein kinase signaling pathway.

    Sung JY et al (2012) Vascul Pharmacol 56(1-2) : 1-8.
    PubMedID: 21708289

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