Nifedipine
(HB1228)- Data
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Data
Product overview
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Name
Nifedipine
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Short description
L-type Ca2+ channel blocker
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Biological description
L-type Ca2+ channel blocker. Causes down regulation of NF-κB, proinflammatory cytokines and cell adhesion molecules. Reduces oxidative stress and smooth muscle cell proliferation and shows potential actions against atherosclerosis. Shows neuroprotective actions for dopaminergic neurones and acts as a vasodilator.
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Biological action
Blocker
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Purity
>98%
- Citations
Properties
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Chemical name
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddimethylester
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Molecular Weight
346.34
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Chemical structure
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Molecular Formula
C17H18N2O6
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CAS Number
21829-25-4
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PubChem identifier
4485
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SMILES
CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
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InChi
InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
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InChiKey
HYIMSNHJOBLJNT-UHFFFAOYSA-N
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MDL number
MFCD00057326
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Appearance
Yellow solid
Storing and Using Your Product
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Storage instructions
+4°C (desiccate)
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Solubility overview
Soluble in DMSO (100mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Nifedipine
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Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses.
Daschil N et al (2014) Brain Res 1581 : 1-11.PubMedID: 25038562 -
Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB.
S K S S et al (2012) Respir Physiol Neurobiol 183(1) : 26-34.PubMedID: 22627105 -
Nifedipine inhibits vascular smooth muscle cell proliferation and reactive oxygen species production through AMP-activated protein kinase signaling pathway.
Sung JY et al (2012) Vascul Pharmacol 56(1-2) : 1-8.PubMedID: 21708289
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