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Biological Data

Biological description L-type Ca2+ channel blocker. Causes down regulation of NF-κB, proinflammatory cytokines and cell adhesion molecules. Reduces oxidative stress and smooth muscle cell proliferation and shows potential actions against atherosclerosis. Shows neuroprotective actions for dopaminergic neurones and acts as a vasodilator.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddimethylester
Molecular Weight 346.34
Chemical structure Nifedipine  [21829-25-4] Chemical Structure
Molecular Formula C17H18N2O6
CAS Number 21829-25-4
PubChem identifier 4485
SMILES CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
InChi InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
InChiKey HYIMSNHJOBLJNT-UHFFFAOYSA-N
MDL number MFCD00057326
Appearance Yellow solid

References for Nifedipine

References are publications that support the biological activity of the product
  • Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses.

    Daschil N et al (2014) Brain Res 1581 : 1-11.
  • Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB.

    S K S S et al (2012) Respir Physiol Neurobiol 183(1) : 26-34.
  • Nifedipine inhibits vascular smooth muscle cell proliferation and reactive oxygen species production through AMP-activated protein kinase signaling pathway.

    Sung JY et al (2012) Vascul Pharmacol 56(1-2) : 1-8.

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