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Data

Product overview

  • Name
    Nociceptin
  • Short description
    Endogenous NOP agonist. Involved in a variety of physiological processes.
  • Biological description

    Nociceptin is a 17-amino acid neuropeptide which is the endogenous ligand for the nociceptin (NOP) receptor (previously known as ORL1). Nociceptin shows no activity at the classical μ, δ or κ opioid receptors.


    The neuropeptide is active in vivo and is involved in a variety of physiological processes. For example, it has been shown to be involved in pain, anxiety, depression, obesity, addiction, hyperphagia, Parkinson’s ,cognition, cardiovascular, inflammatory and learning and memory.

  • Alternative names
    N/OFQ, Orphanin FQ,
  • Biological action
    Activator
  • Citations

Properties

  • Chemical name
    FGGFTGARKSARKLANQ
  • Molecular Weight
    1809.07
  • Chemical structure
    Nociceptin  [170713-75-4]
  • Molecular Formula
    C79H129N27O22
  • Sequence (one letter)
    FGGFTGARKSARKLANQ
  • Sequence (three letter)
    Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln
  • CAS Number
    170713-75-4
  • PubChem identifier
    16131448
  • SMILES
    C[C@H]([C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)N)O
  • InChiKey
    PULGYDLMFSFVBL-SMFNREODSA-N
  • Protein length
    17

Storing and Using Your Product

  • Storage instructions
    Desiccate at -20°C
  • Solubility overview
    Soluble in water (1 mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for Nociceptin

  • Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands.

    Pacifico et al (2017) Sci Rep. 6 : 7:45817
    PubMedID: 28383520
  • Evidence for nociceptin/orphanin FQ (NOP) but not µ (MOP), δ (DOP) or κ (KOP) opioid receptor mRNA in whole human blood.

    ASl-Hashimi et al (2016) Br J Anaesth 116(3) : 423-9
    PubMedID: 26865135
  • The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation.

    Bongsebandhu-phubhakdi et al (2007) J Neurosci 27(18) : 4850-8
    PubMedID: 17475793
  • The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.

    Witkin et al (2014) Pharmacol Ther 141(3) : 283-99
    PubMedID: 24189487
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