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Nocodazole

(HB3999)
Data

Product overview

  • Name
    Nocodazole
  • Short description
    Mitosis inhibitor. Widely used as a cell cycle synchronizing agent.
  • Biological description
    Mitosis inhibitor which which induces microtubule depolymerization in vivo and inhibits tubulin polymerziation. Arrest cell cycle at the G2/M phase. Widely used as a cell cycle synchronizing agent. Enhances homology-directed repair (HDR) efficiency (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Molecular Weight
    301.3
  • Chemical structure
    Nocodazole [31430-18-9]
  • CAS Number
    31430-18-9
  • InChiKey
    KYRVNWMVYQXFEU-UHFFFAOYSA-N
  • Appearance
    White to off-white solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Nocodazole

  • Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.

    Vasquez et al (1997) Mol Biol Cell 8(6): : 973-85
    PubMedID: 9201709
  • Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases.

    Webb et al (2004) Int J Biochem Cell Biol 36(12) : 2541-50.
    PubMedID: 15325591
  • Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery.

    Lin et al (25497837) Elife 15(3) : e04766
    PubMedID: 25497837
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