Nω-Propyl-L-arginine hydrochloride

(HB0466)

Product overview

  • Name
    Nω-Propyl-L-arginine hydrochloride
  • Short description
    Potent, selective nNOS inhibitor
  • Biological description
    Potent and selective nNOS inhibitor (Ki = 50 nM). Highly selective for nNOS over eNOS and iNOS. Shows anti-convulsant actions and decreases blood pressure.
  • Alternative names
    L-NPA
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    N5-[Imino(propylamino)methyl]-L-ornithine hydrochloride
  • Molecular Weight
    252.74
  • Chemical structure
    Nω-Propyl-L-arginine hydrochloride  [137361-05-8]
  • Molecular Formula
    C9H20N4O2.HCl
  • CAS Number
    137361-05-8

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in water (100mM) or DMSO (100nM)

References for Nω-Propyl-L-arginine hydrochloride

  • Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.

    Zhang HQ et al (1997) J Med Chem 40(24) : 3869-70.
    PubMedID: 9397167
  • The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney.

    Kakoki M et al (2001) Am J Physiol Regul Integr Comp Physiol 281(1) : R91-7.
    PubMedID: 11404282
  • N(w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.

    Beamer E et al (2012) Eur J Neurosci 36(9) : 3194-203.
    PubMedID: 22943535
  • The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney.

    Kakoki M et al (2001) Am J Physiol Regul Integr Comp Physiol 281(1) : R91-7.
    PubMedID: 11404282

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