NPC-15437 dihydrochloride

(HB0457)

Order: HB0457

Pack	Price	Qty
10mg	$291
50mg	$1,038

(HB0457)

Data

Product overview

Name
NPC-15437 dihydrochloride
Short description
Competitive, selective PKC inhibitor
Biological description
Competitive and selective protein kinase C (PKC) inhibitor (IC₅₀ = 19.0 µM) that interacts at N terminal of C1 domain. Shows selectivity for PKC-α over PKC-HH and PKC-CB (IC₅₀ values are 22, 30, 130 µM respectively). Exhibits little or no activity for cAMP-dependent or calcium/calmodulin-dependent protein kinase (IC₅₀ values >300 µM). Displays neuroprotective properties.
Biological action
Inhibitor
Citations
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Storage instructions
+4°C
Solubility overview
soluble in water or DMSO
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C.

Sullivan JP et al (1991) Agents Actions 34(1-2) : 142-4.
PubMedID: 1793019
2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain.

Sullivan JP et al (1992) Mol Pharmacol 41(1) : 38-44.
PubMedID: 1732721
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.

Sullivan JP et al (1991) FEBS Lett 285(1) : 120-3.
PubMedID: 2065775
The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice.

Mathis C et al (1992) Eur J Pharmacol 220(1) : 107-10.
PubMedID: 1425976

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