NPC-15437 dihydrochloride

(HB0457)

Product overview

  • Name
    NPC-15437 dihydrochloride
  • Short description
    Competitive, selective PKC inhibitor
  • Biological description
    Competitive and selective protein kinase C (PKC) inhibitor (IC50 = 19.0 µM) that interacts at N terminal of C1 domain. Shows selectivity for PKC-α over PKC-HH and PKC-CB (IC50 values are 22, 30, 130 µM respectively). Exhibits little or no activity for cAMP-dependent or calcium/calmodulin-dependent protein kinase (IC50 values >300 µM). Displays neuroprotective properties.
  • Biological action
    Inhibitor
  • Our products in action

Properties

  • Molecular Weight
    511.62
  • Chemical structure
    NPC-15437 dihydrochloride  [136449-85-9]
  • Molecular Formula
    C25H50N4O2.2HCl
  • CAS Number
    136449-85-9
  • PubChem identifier
    16219723
  • SMILES
    CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@H](CCCCN)N.Cl.Cl

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in water or DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NPC-15437 dihydrochloride

  • 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C.

    Sullivan JP et al (1991) Agents Actions 34(1-2) : 142-4.
    PubMedID: 1793019
  • 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain.

    Sullivan JP et al (1992) Mol Pharmacol 41(1) : 38-44.
    PubMedID: 1732721
  • NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.

    Sullivan JP et al (1991) FEBS Lett 285(1) : 120-3.
    PubMedID: 2065775
  • The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice.

    Mathis C et al (1992) Eur J Pharmacol 220(1) : 107-10.
    PubMedID: 1425976

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