Product overview

Name NPC-15437 dihydrochloride
Description Competitive, selective PKC inhibitor
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Biological Data

Biological description Competitive and selective protein kinase C (PKC) inhibitor (IC50 = 19.0 µM) that interacts at N terminal of C1 domain. Shows selectivity for PKC-α over PKC-HH and PKC-CB (IC50 values are 22, 30, 130 µM respectively). Exhibits little or no activity for cAMP-dependent or calcium/calmodulin-dependent protein kinase (IC50 values >300 µM). Displays neuroprotective properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water or DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Molecular Weight 511.62
Chemical structure NPC-15437 dihydrochloride  [136449-85-9] Chemical Structure
Molecular Formula C25H50N4O2.2HCl
CAS Number 136449-85-9
PubChem identifier 16219723
SMILES CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@H](CCCCN)N.Cl.Cl

References for NPC-15437 dihydrochloride

References are publications that support the biological activity of the product
  • The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice.

    Mathis C et al (1992) Eur J Pharmacol 220(1) : 107-10.
  • 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain.

    Sullivan JP et al (1992) Mol Pharmacol 41(1) : 38-44.
  • NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.

    Sullivan JP et al (1991) FEBS Lett 285(1) : 120-3.
  • 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C.

    Sullivan JP et al (1991) Agents Actions 34(1-2) : 142-4.

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