NS 1619

(HB1048)

Product overview

  • Name
    NS 1619
  • Short description
    Potent, selective KCa1.1 channel activator
  • Biological description
    Potent and selective KCa1.1 channel activator (EC50 = 3.6 µM). Selectively increases the blood brain barrier permeability. Displays vasorelaxant properties
  • Biological action
    Activator
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    1,3-Dihydro-1-[2-hydroxy-5-(trifluo romethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
  • Molecular Weight
    362.23
  • Chemical structure
    NS 1619  [153587-01-0]
  • Molecular Formula
    C15H8F6N2O2
  • CAS Number
    153587-01-0

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NS 1619

  • Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.

    Debska G et al (2003) Biochem Pharmacol 65(11) : 1827-34.
    PubMedID: 12781334
  • Role of ROS/RhoA/PI3K/PKB signaling in NS1619-mediated blood-tumor barrier permeability increase.

    Gu YT et al (2012) J Mol Neurosci 48(1) : 302-12.
    PubMedID: 22581438
  • 5-(4'-Substituted-2'-nitroanilino)-1,2,3-triazoles as new potential potassium channel activators. I.

    Biagi G et al (2000) Eur J Med Chem 35(7-8) : 715-20.
    PubMedID: 10960187
  • Large conductance Ca2+ -activated K+ channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle.

    Soder RP et al (2011) Eur J Pharmacol 670(1) : 252-9.
    PubMedID: 21914438

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