Product overview

  • Name
    NS 1643
  • Short description
    Kv11.1 channel activator
  • Biological description
    Kv11.1 channel activator (EC50 = 10.5 µM). Also activates Kv11.2 channels via different mechanism and Kv11.3 channels. A diphenylurea derivative that irreversibly inhibits cell proliferation.
  • Biological action
    Activator
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    N,N'-Bis[2-hydroxy-5-(trifluoromethy l)phenyl]urea
  • Molecular Weight
    380.24
  • Chemical structure
    NS 1643  [448895-37-2]
  • Molecular Formula
    C15H10F6N2O3
  • CAS Number
    448895-37-2

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in ethanol (100mM) or DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NS 1643

  • Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

    Hansen RS et al (2006) Mol Pharmacol 69(1) : 266-77.
    PubMedID: 16219910
  • Activation of ERG2 potassium channels by the diphenylurea NS1643.

    Elmedyb P et al (2007) Neuropharmacology 53(2) : 283-94.
    PubMedID: 17610913
  • Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program.

    Lansu K et al (2013) Cell Death Dis 4 : e652.
    PubMedID: 23744352
  • Effects of the small molecule HERG activator NS1643 on Kv11.3 channels.

    Bilet A et al (2012) PLoS One 7(11) : e50886.
    PubMedID: 23226420

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