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Biological Data

Biological description Kv11.1 channel activator (EC50 = 10.5 µM). Also activates Kv11.2 channels via different mechanism and Kv11.3 channels. A diphenylurea derivative that irreversibly inhibits cell proliferation.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in ethanol (100mM) or DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name N,N'-Bis[2-hydroxy-5-(trifluoromethy l)phenyl]urea
Molecular Weight 380.24
Chemical structure NS 1643  [448895-37-2] Chemical Structure
Molecular Formula C15H10F6N2O3
CAS Number 448895-37-2
PubChem identifier 10177784
SMILES OC1=C(NC(NC2=C(O)C=CC(C(F)(F)F)=C2)=O)C=C(C(F)(F)F)C=C1
InChiKey NJFVQMRYJZHGME-UHFFFAOYSA-N

References for NS 1643

References are publications that support the biological activity of the product
  • Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program.

    Lansu K et al (2013) Cell Death Dis 4 : e652.
  • Effects of the small molecule HERG activator NS1643 on Kv11.3 channels.

    Bilet A et al (2012) PLoS One 7(11) : e50886.
  • Activation of ERG2 potassium channels by the diphenylurea NS1643.

    Elmedyb P et al (2007) Neuropharmacology 53(2) : 283-94.
  • Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

    Hansen RS et al (2006) Mol Pharmacol 69(1) : 266-77.

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