NS 309

(HB1049)

Product overview

  • Name
    NS 309
  • Short description
    Potent, selective KCa3.1 / KCa2 channel subfamily activator
  • Biological description
    Potent and selective KCa3.1 channel and KCa2 channel subfamily activator (EC50 = 0.3 µM for KCa2.3). Exhibits little or no activity at KCa1.1 channels. Displays >1000 fold higher potency than 1-EBIO.
  • Biological action
    Activator
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    6,7-Dichloro-1H-indole-2,3-dione 3-oxime
  • Molecular Weight
    231.04
  • Chemical structure
    NS 309  [18711-16-5]
  • Molecular Formula
    C8H4Cl2N2O2
  • CAS Number
    18711-16-5

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NS 309

  • Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

    Strøbaek D et al (2004) Biochim Biophys Acta 1665(1-2) : 1-5.
    PubMedID: 15471565
  • NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels.

    Parajuli SP et al (2013) Br J Pharmacol 168(7) : 1611-25.
    PubMedID: 23145946
  • Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels.

    Hougaard C et al (2007) Br J Pharmacol 151(5) : 655-65.
    PubMedID: 17486140

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